Search results for: hair-cell-regeneration-repair-and-protection

Hair Cell Regeneration Repair and Protection

Author : Richard J. Salvi
File Size : 41.62 MB
Format : PDF, Mobi
Download : 858
Read : 881
Download »
Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.

Sensory Hair Cell Death and Regeneration

Author : Michael E. Smith
File Size : 84.50 MB
Format : PDF, Mobi
Download : 845
Read : 1290
Download »
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.

Hearing Loss Mechanisms Prevention and Cure

Author : Huawei Li
File Size : 37.55 MB
Format : PDF, Docs
Download : 133
Read : 1325
Download »
This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients’ ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialists and researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.

Cochlear Implants

Author : Susan B. Waltzman
File Size : 32.19 MB
Format : PDF, Docs
Download : 583
Read : 228
Download »
Covering all aspects of cochlear implantation and related sciences for the many specialists working in the field, this volulme emphasises the most recent developments in basic and clinical sciences, including: the effects of electrical stimulation; processing capabilities; preoperative criteria; medical, surgical and radiological issues; device programming; rehabilitation; and education. It discusses the full continuum of care in cochlear implantation in adults and children -- combining basic principles and theory with practical clinical management. Also: complete sections on hair cell regeneration, deprivation and effects of electrical stimulation; a full section on cochlear implant imaging -- never available before; new perspectives on outcomes measurement; and future directions in implant design and processing strategies.

The Lateral Line System

Author : Sheryl Coombs
File Size : 38.62 MB
Format : PDF, Mobi
Download : 299
Read : 375
Download »
The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information is shaped and encoded by the peripheral and central nervous systems. Contents The Gems of the Past: A Brief History of Lateral Line Research in the Context of the Hearing Sciences - Sheryl Coombs and Horst Bleckmann Morphological Diversity, Development, and Evolution of the Mechanosensory Lateral Line System - Jacqueline F. Webb The Hydrodynamic of Flow Stimuli - Matthew J. McHenry and James C. Liao The Biophysics of the Fish Lateral Line - Sietse M. van Netten and Matthew J. McHenry Sensory Ecology and Neuroethology of the Lateral Line - John Montgomery, Horst Bleckmann, and Sheryl Coombs Information Encoding and Processing by the Peripheral Lateral Line System - Boris Philippe Chagnaud and Sheryl Coombs The Central Nervous Organization of the Lateral Line System - Mario F. Wullimann and Benedikt Grothe Central Processing of Lateral Line Information - Horst Bleckmann and Joachim Mogdans Functional Overlap and Nonoverlap Between Lateral Line and Auditory Systems - Christopher B. Braun and Olav Sand The Hearing Loss, Protection, and Regeneration in the Larval Zebrafish Lateral Line - Allison B. Coffin, Heather Brignull, David W. Raible, and Edwin W Rubel

Translational Research in Audiology Neurotology and the Hearing Sciences

Author : Colleen G. Le Prell
File Size : 79.43 MB
Format : PDF, ePub, Mobi
Download : 597
Read : 1292
Download »
Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Most scientific training programs provide little or no systematic introduction to the issues, challenges, and obstacles that prevent effective research translation, even though these are the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome. This volume will provide an overview of key issues in translation of research from “bedside to bench to bedside”, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in the translational research process. It will attempt to offer insight into real-world experience with intellectual property and technology transfer activities that can help move auditory technologies ahead, as scientists and clinicians typically have little or no formal training in these areas. Translational Research in Audiology and the Hearing Sciences will be aimed at graduate students and postdoctoral investigators, as well as professionals and academics. It is intended to function as a high-profile and up-to-date reference work on Translational Research in the auditory sciences, emphasizing research programs in the traditional areas including drugs and devices, as well as less traditional, still emerging, areas such as sensorineural hearing loss, auditory processing disorder, cochlear implants and hearing aids, and tinnitus therapies.

Cell and Molecular Biology of the Ear

Author : David J. Lim
File Size : 66.26 MB
Format : PDF, ePub, Docs
Download : 247
Read : 532
Download »
Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946. Two grateful patients of Dr. House put forth the idea that his knowledge and innovative skills could be used to expand the understanding of hearing impairment and its treatment. Those two early patients provided the "seed money" to begin the Institute. Since that time, the growth has been phenomenal from a one-man laboratory to a multidisciplinary facility boasting over 175 scien tists, physicians, and support staff, all dedicated to the advancement of otologic research and education. Six years ago after a half-century of remarkable success with prosthetic and device research, the Institute began cultivating a new field of endeavor-cell and molecular biology. Don Nielsen, then the Institute's Executive Vice President for Research and Scientific Director, began exploring the potential for hair cell regen eration and presented his ideas to the Board of Trustees. For a period of six months, we did a lot of fact finding to assess what role the Institute might take in this excit ing new field.

Auditory System Plasticity and Regeneration

Author : Richard Salvi
File Size : 35.58 MB
Format : PDF, ePub, Mobi
Download : 201
Read : 891
Download »
Contributions from leading international specialists critically document the rapid and substantive progress achieved in understanding plasticity and regeneration of the adult auditory system. Articles synthesize what is currently known about the principles and mechanisms of hair cell regeneration and identify future research directions in this challenging area of hearing science.

DNA and Cell Biology

Author :
File Size : 49.4 MB
Format : PDF, ePub, Mobi
Download : 808
Read : 1052
Download »

Noise Health

Author :
File Size : 72.49 MB
Format : PDF, ePub
Download : 970
Read : 812
Download »

Manual of School Health E Book

Author : Keeta DeStefano Lewis
File Size : 58.60 MB
Format : PDF, Mobi
Download : 322
Read : 765
Download »
Completely updated, the 3rd edition of this practical, highly portable manual offers quick access to the most relevant health and wellness information for children -- from birth through age 21 – in the school setting. You’ll find valuable guidance on developmental stages, learning domains, acute and chronic illnesses, first aid, medical syndromes, special education, and emergency illness. This edition also addresses the growing array of issues affecting today’s children, including mental health disorders, disaster management, substance abuse, and school violence, as well as new threats such as West Nile virus, dermatological conditions, and the reemergence of tuberculosis. Ideal for use in school and community settings, this manual is a must-have resource for anyone who works with children. A best practice approach to health issues and concerns helps you provide the best possible care to students. A clear, consistent outline format and straightforward writing style make it easy to locate and apply essential information. Updated content includes important contemporary issues in schools, such as body piercing, backpack syndrome, and computer ergonomics. Brain Findings section offers relevant information about recent brain and neurology research, with insights on how it relates to childhood development and health. Numerous appendices, including the latest growth charts and immunization schedules, provide essential information for assessing school age children. English-Spanish translation guide for common health terms and phrases helps you communicate more effectively with Hispanic students. Web site resources at the end of each chapter provide reliable sources for further information and research. A convenient Glossary familiarizes you with important terminology and definitions used throughout the book. New, user-friendly design helps you find key information quickly with helpful boxes, tables, and headings. New 8-page color insert serves as an instant visual reference to help you identify rashes, skin lesions, and other dermatological conditions that are common among school-age children. A separate chapter on first aid walks you through the management of common injuries and emergency situations. Revised mental health chapter presents current, detailed information on the major mental disorders that affect school-age children such as depression, autism, and Asperger's, with an extensive psychotropic medication table. A new chapter devoted to disaster management includes the latest information on bioterrorism and homeland security threats to help you create an action plan for disaster situations. A revised chapter on violence addresses sexual assault, self-mutilation, suicide, domestic violence, and violence in the schools, to help you stay informed about current societal trends, issues, and developments. New information on teen pregnancy offers helpful guidelines on communicating with students about this important issue.

Acta oto rhino laryngologica Belgica

Author :
File Size : 82.28 MB
Format : PDF, ePub, Docs
Download : 393
Read : 999
Download »

Ear Nose Throat Journal

Author :
File Size : 78.72 MB
Format : PDF, ePub
Download : 345
Read : 580
Download »

Annals of the Academy of Medicine Singapore

Author : Academy of Medicine (Singapore)
File Size : 78.59 MB
Format : PDF, ePub, Mobi
Download : 882
Read : 1005
Download »

Scientific Basis of Noise induced Hearing Loss

Author :
File Size : 42.4 MB
Format : PDF, Kindle
Download : 856
Read : 1222
Download »

General and Applied Toxicology

Author : Bryan Ballantyne
File Size : 49.31 MB
Format : PDF, ePub, Mobi
Download : 478
Read : 843
Download »

Clinical Applications of Neurotrophic Factors

Author : Stuart C. Apfel
File Size : 26.64 MB
Format : PDF, ePub, Docs
Download : 926
Read : 1165
Download »

Dermatology E Book

Author : Jean L. Bolognia
File Size : 54.52 MB
Format : PDF, ePub
Download : 245
Read : 884
Download »
Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest practices in dermatologic diagnosis and treatment at your fingertips. It delivers more comprehensive coverage of basic science, clinical practice, pediatric dermatology, and dermatologic surgery than you’ll find in any other source. Whether you’re a resident or an experienced practitioner, you’ll have the in-depth, expert, up-to-the-minute answers you need to overcome any challenge you face in practice. Find answers fast with a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and algorithms for instant visual comprehension. Get full exposure to core knowledge with coverage of dermatology’s entire spectrum of subspecialties. See just the essential information with "need-to-know" basic science information and key references. Expedite decision making and clarify complex concepts with logical tables, digestible artwork, and easy-to-grasp schematics. Visualize more of the conditions you see in practice with over 3500 illustrations, of which over 1,400 are new: 1,039 clinical images, 398 pathology slides, and 152 schematics. Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color. Get an enhanced understanding of the foundations of dermatology in pathology, the clinical setting, and dermoscopy with a completely rewritten introductory chapter. Better comprehend the clinical-pathological relationship of skin disease with increased histologic coverage. Bolognia’s Dermatology is the ultimate multimedia reference for residents in training AND the experienced practitioner.

Molecular Biology of the Cell

Author :
File Size : 80.96 MB
Format : PDF, ePub, Docs
Download : 539
Read : 260
Download »

Noise induced Hearing Loss

Author : Armand L. Dancer
File Size : 36.10 MB
Format : PDF, Mobi
Download : 328
Read : 1143
Download »