Search results for: protein-biosynthesis

Protein Biosynthesis

Author : Alan E. Smith
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46 3. 2 mRNA metabolism 47 3. 3 Initiation complex formation 3. 3. 1 Binding of initiator tRNA 47 3. 3. 2 Binding of messenger RNA 50 3. 4 Elongation 56 3. 5 Termination of protein biosynthesis and post-translational modification 59 RNA phage protein synthesis 61 3. 6 References 63 Index 64 1 Introduction possible control processes operating to adjust 1. 1 The problem protein synthesis to the needs of the cells and The discovery that the genetic material of organism. It will be assumed that the reader has living organisms is DNA, and the later de some knowledge of molecular biology in gen monstration that the DNA molecule is a eral and protein biosynthesis in particular, but double helix were both great milestones in twentieth century science, and formed the by way of introduction each of the major molecules and stages of the process will be foundation of the new discipline of molecular described in simple terms, and in subsequent biology. But even after these momentous dis chapters each will be discussed again in coveries, the detailed mechanism by which such genetic material could be expressed as the struc greater depth. tural and catalytic proteins which play so im portant a role in the functioning of all living 1. 2 Overall steps in protein biosynthesis The information encoded in the two comple cells was still not obvious.

Protein Biosynthesis in Eukaryotes

Author : R. Perez-Bercoff
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vi The word ppotein, coined one and a half century ago from the 1TpOTE:toa ("proteios" = of primary importance), underlines the "primary importance" ascribed to proteins from the time they were described as biochemical entities. But the unmatched compl~xity of the process involved in their biosynthesis was (understandably) overlooked. Indeed, protein biosynthesis was supposed to be nothing more than the reverse of protein degradation, and the same enzymes known to split a protein into its constituent amino acids were thought to be able, under adequate conditions, to reconstitute the peptide bond. This oversimplified view persisted for more than 50 years: It was just in 1940 that Borsook and Dubnoff examined the thermodynamical aspects of the process, and concluded that protein synthesis could not be the reverse of protein degradation, such an "uphill task being thermody namically impossible ••• • " The next quarter of a century witnessed the unravelling of the basic mechanisms of protein biosynthesis, a predictable aftermath of the Copernican revolution in biology which followed such dramatic de velopments as the discovery of the nature of the genetic material, the double helical structure· of DNA, and the determination of the ge netic code. Our present understanding of the sophisticated mechan isms of regulation and control is a relatively novel acquisition, and recent studies have shed some light into the structure and organi zation of the eukaryotic gene.

Protein Biosynthesis Interference in Disease

Author : Elena L. Paley
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Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes. Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis

Inhibitors of Protein Biosynthesis

Author : David Vázquez
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Protein Biosynthesis

Author : H. R. Arnstein
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The subject of protein synthesis is central to any study of biochemistry. This book provides a clear, accessible introduction to the mechanisms and processes involved. Included are chapters giving background theory, descriptions of the structure and function of the ribosome, and the regulationof protein synthesis. Experienced researchers, as well as students in other areas, will find this book to be a well-structured, concise summary of the principles underlying a very important topic, one which is not covered as a cohesive whole in existing textbooks.

Molecular Mechanisms of Protein Biosynthesis

Author : Herbert Weissbach
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Molecular Mechanisms of Protein Biosynthesis is a collection of papers dealing with cell-free systems at the molecular level, including transfer RNA; the initiation, elongation, and termination processes; ribosome structure and function; mRNA translation; and DNA-directed in vitro protein synthesis. A couple of papers review tRNA, aminoacyl-tRNA synthetases, and aspects of ribosome structure. One paper discusses affinity labeling in the study of binding and catalytic sites of large complex and heterogeneous systems such as the ribosome. The investigator should be aware of the chemically reactive or photoactivatible analogue reacting specifically with one or more ribosomal components. This reaction should be determined if it is dependent on the correct binding of the affinity label at the functional site. Another paper describes the series of reactions in protein synthesis as the process by which the ribosome moves relative to the messenger RNA. Other papers discuss messenger RNA and its translation, DNA-dependent cell-free protein synthesis, as well as the genetics of the translational apparatus. The collection will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.

Protein Biosynthesis Advances in Research and Application 2012 Edition

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Protein Biosynthesis—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Protein Biosynthesis in a compact format. The editors have built Protein Biosynthesis—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Biosynthesis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein Biosynthesis—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Protein Biosynthesis in Eukaryotes

Author : Italy) NATO Advanced Study Institute on Protein Biosynthesis in Eukaryotes (1980 : Maratea
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Protein Biosynthesis in Nonbacterial Systems

Author : Jerold A. Last
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Preparation of skeletal muscle ribosomes and assay of protein synthesis. Isolation of mammalian cell polyribosomes. Tissue culture polyribosomal systems. Polyribosomes and cell-free protein synthesis in the spleen. Protein synthesis in extracts of wheat embryo. Cerebral protein-synthesizing systems. Protein biosynthesis in paramecium with special reference to the in vitro systhesis of the cell surface antigens. Preparation and assay of hemoglobin mRNA. Preparation and assay of reticulocyte initiation factors. Preparation and mode of action of interferon.

Techniques in Protein Biosynthesis

Author : Peter Nelson Campbell
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Aspects of Protein Biosynthesis

Author : Christian Boehmer Anfinsen
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Protein Biosynthesis

Author : Toma E. Esterhouse
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Protein biosynthesis (synthesis) is the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and transcription which are then used for translation. Protein biosynthesis, although very similar, differs between prokaryotes and eukaryotes. This book presents important research in the field from around the globe.

Alcohol and Abnormal Protein Biosynthesis

Author : Marcus A. Rothschild
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Alcohol and Abnormal Protein Biosynthesis: Biochemical and Clinical focuses on the methods for measuring protein metabolism and the effects of alcohol and altered protein intake as they affect the heart, liver, skeletal muscle, and the brain. Organized into six sections, this book begins with an overview on malnutrition and alcoholism, as well as available techniques for the study of protein synthesis. Subsequent section details the adaptation of protein synthesis and transport to alcohol and malnutrition. Section three discusses the skeletal and cardiac muscle protein metabolism. The last three sections describe the reaction of hepatic protein synthesis to malnutrition and alcohol; effects of alcohol on brain RNA metabolism; and alcohol associated cardiac and hepatic disease.

Techniques in Protein Biosynthesis

Author : Peter Nelson Campbell
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Amino Acid and Protein Biosynthesis II

Author : H. R. Arnstein
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Synthesis of Amino Acids and Proteins

Author : H. R. V. Arnstein
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Functional Units in Protein Biosynthesis

Author : Federation of European Biochemical Societies
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Protein Biosynthesis in Bacterial Systems

Author : Jerold A. Last
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Protein Synthesis and Ribosome Structure

Author : Knud H. Nierhaus
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Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

Protein Biosynthesis and Membrane Biochemistry

Author : Richard W. Hendler
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